Edward's syndrome

Edward's syndrome is a rarer cause of mental retardation than Down's syndrome, and a more severe disease. About 30% of babies with this condition die in the first month and fewer than 10% survive the first year.

The incidence of this condition is about 1 per 6000 live births, with a male to female ratio of 1:2. There is a weak association with advanced maternal age.

• genetics
• clinical features
• ultrasound in the diagnosis of trisomy 18

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