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UPET phase 1 trial

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In the phase 1 of the UPET trial 160 patients with pulmonary embolism were randomised to a 24 hr urokinase infusion followed by heparin or heparin alone.

Subjectively the thrombolysed group showed more rapid clot lysis. Objectively there were non-significant trends toward reduced mortality and less frequent recurrent embolism.

Reference:

  • The Urokinase Pulmonary Embolism Trial. A national cooperative study. (1973). Circulation 47, 1-108.
 
General Practice Notebook
General Practice Notebook
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