In the phase 1 of the UPET trial 160 patients with pulmonary embolism were randomised to a 24 hr urokinase infusion followed by heparin or heparin alone.
Subjectively the thrombolysed group showed more rapid clot lysis. Objectively there were non-significant trends toward reduced mortality and less frequent recurrent embolism.
- The Urokinase Pulmonary Embolism Trial. A national cooperative study. (1973). Circulation 47, 1-108.