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Diagnosis is made on the basis of: - high fasting plasma gastrin
-
high gastric acid secretion:
- usually in excess of 100 mmol/h
-
diminished response to pentagastrin
localisation of tumour: -
demonstrable pancreatic or gastrointestinal tumour - by CT or venous sampling
for gastrin
- more than 90% of gastrinomas have somatostatin receptors,
and somatostatin receptor scintigraphy has been reported to be an especially sensitive
method to image gastrinomas (1)
- also, with a skilled operator, endoscopic
ultrasonography (also combined with biopsy) is also a very sensitive method to
detect pancreatico-duodenal tumours
Reference: - de Herder
WW and Lamberts SWJ. Best Practice & Research Clinical Endocrinology & Metabolism
2004; Volume 18(4): 477-495.
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