Methyl dopa is a centrally-acting antihypertensive drug that is gradually declining in usage. It inhibits decarboxylation of dopa to dopamine. Therapy is associated with reduced concentrations of dopamine, 5 - hydroxytryptamine and noradrenaline in peripheral tissues and the CNS. This drug is associated with a reduction in renin levels.

Indications for the use of methyl dopa include:

• hypertension, in conjunction with a diuretic
• hypertensive crisis when an immediate effect is not necessary

Cautions/Contraindications:

• history of depression
• active liver disease
• porphyria
• phaeochromocytoma
• increases the CNS toxicity of lithium