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Take expert advice - for example, from the Bureau of Hygiene and Tropical Medicine,
London. - prevention of cholera depends primarily on improving
sanitation and water supplies in endemic areas and on scrupulous personal and
food and water hygiene. While new oral cholera vaccines can provide individual
protection against V. cholerae O1, their role in endemic and outbreak conditions
is not yet defined
- the only cholera vaccine licensed in the UK since
May 2004 is Dukoral®, a killed V. cholerae whole-cell (WC) vaccine with recombinant
B subunit of cholera toxin (rCTB), administered orally. Intramuscular cholera
vaccines are no longer recommended for use
Note however that Dukoral
is an oral, killed recombinant B-subunit/whole-cell cholera vaccine (BS/WC)
- Dukoral has been licensed in Sweden since 1991
- the BS/WC vaccine
is indicated for active immunisation against disease caused by Vibrio cholerae
serogroup O1 in adults and children from 2 years of age who will be visiting endemic/epidemic
areas
- this is the only cholera vaccine currently recommended by the WHO
for the pre-emptive vaccination of populations at immediate risk of a cholera
epidemic (1)
Reference: - World Health Organization Cholera
2002. Wkly Epidemiological Record 2003, 78, 269-276.
- New cholera vaccines
- for whom? Lancet 344 (1994): 1241
- Immunisation Against Infectious Disease
- "The Green Book".Chapter 14 Cholera (August 2006)
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