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progesterone synthesis

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Endogenous progesterone is synthesized from pregnenolone by formation of a keto group at the C3 position and transfer of a double bond between C5-6 and C4-5.

It can then be used to produce either:

  • 17-alpha-hydroxyprogesterone, an intemediate, by hydroxylation at C17, or
  • 11-desoxycorticosterone

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