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The tumour lysis syndrome:
- generally occurs in patients with lymphoproliferative malignancies, most
often after initiation of treatment
- pathophysiology of tumour lysis syndrome involves massive tumor cell lysis
- this leads to the release of large amounts of potassium, phosphate, and
uric acid
- deposition of uric acid and calcium phosphate crystals in the renal tubules
may cause acute renal failure, which is often exacerbated by concomitant
intravascular volume depletion. These products are normally renally excreted
- therefore preexisting renal failure exacerbates the metabolic derangements
of tumor lysis syndrome
Reference:
- Davidson
MB et al. Pathophysiology, clinical consequences, and treatment of tumor lysis
syndrome. Am J Med. 2004;116(8):546-5
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