Duchenne muscular dystrophy is a common and possibly the best known muscular
dystrophy. It follows an aggressive and progressive course.
is inherited in an X-linked manner although up to 30% of cases represent new mutations.
The gene for Duchenne muscular dystrophy is the dystrophin locus at Xp21.
in approximately 1 in 3500 male births, and in about 1 in 50 000 000 female births
with a mutant X chromosome will not have DMD, but they will be carriers of the
- those very rare females who have DMD are believed to either carry
mutant genes on both X chromosomes, or have an inactivated healthy X chromosome
- the prevalence of Duchenne's muscular dystrophy
varies with respect to different populations. However, in a study of neuromuscular
disease in Northern Ireland, Duchenne muscular dystrophy was found to have the
second highest prevalence, after myotonic dystrophy (2).
CL. Parents' perspectives on coping with Duchenne muscular dystrophy. Child Care
Health Dev. 2005 Jul;31(4):385-96.
- Hicks MI et al. The prevalence
of inherited neuromuscular disease in Northern Ireland.Neuromuscul Disord. 1996