This site is intended for healthcare professionals
General Practice Notebook
Medical search

hepatic enzyme inhibitors

FREE subscriptions for doctors and students... click here
You have 3 open access pages.

Drugs which inhibit hepatic enzymes may have the following effects:

  • they may increase the bioavailability of other drugs which are metabolised by those enzymes
  • they may decrease the bioavailability of drugs which require metabolism for their activation

Examples include:

  • alcohol consumed during 'binges'
  • antibiotics:
    • isoniazid
    • erythromycin
    • sulphonamides
    • metronidazole
    • chloramphenicol
    • ketoconazol
  • anticonvulsants, particularly valproate
  • cimetidine
  • allopurinol
  • chlorpromazine
  • imipramine
  • propranolol
  • metoprolol
  • interferon

Reference:

  • Adachi Y et al (1995). Potentiation of warfarin by interferon (letter). BMJ, 311, 292.

Links:

General Practice Notebook
General Practice Notebook
The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions LtdĀ®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions LtdĀ® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.