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Peripheral neuropathy (with autonomic dysfunction)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Neuropathies that may produce severe involvement of autonomic function include:

  • diabetes mellitus: may present with impotence, postural hypotension, diarrhoea and sphincter disturbances. Cardiac denervation may also occur.

  • Guillain-Barre syndrome: may present with autonomic involvement such as cardiac dysrhythmias and labile hypertension.

  • amyloidosis: neuropathy of primary amyloidosis may cause distal pain and temperature loss in the limbs, and trophic ulceration and autonomic symptoms.

  • porphyria
  • renal failure
  • vincristine

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