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lymphocytic colitis

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Microscopic colitis syndrome is defined by the triad of:

  • chronic watery diarrhoea
  • normal mucosal appearance on colonoscopy
  • characteristic histological changes in the mucosal biopsy:
    • lymphocytic infiltration in the lamina propria - when this is marked the disease may be termed lymphocytic colitis
    • variable thickening of the subepithelial collagen layer - when fibrosis is marked the disease may be termed collagenous colitis

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