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Blood tests in liver disease

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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A liver screen should include the following investigations:

  • liver function tests - including gamma GT and total protein
  • ethanol
  • coagulation tests, including INR and APTT
  • hepatitis serology - for A, B, and C
  • viral screen, for CMV, EBV etc
  • ferritin and total iron binding capacity
  • alpha 1 antitrypsin
  • immunoglobulins and protein electrophoresis
  • autoantibody screen
  • alpha-feto protein
  • serum copper, ceruloplasmin, 24 hour copper

A full blood count may detect:

  • anaemia due to gastrointestinal bleeding
  • macrocytosis
  • thrombocytopenia due to:
    • the effects of alcohol on the bone marrow
    • hypersplenism
    • DIC

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