|
Frederickson Classification of Lipid Disorders
| Type |
Average of overnight serum |
Elevated particles |
Associated clinical disorders |
Serum TC |
Serum TG |
| I |
Creamy top layer |
Chylomicrons |
Lipoprotein lipase deficiency, apolipoprotein C-II deficiency
|
N |
++ |
| IIa |
Clear |
LDL |
Familial hypercholesterolemia, polygenic hypercholesterolemia, nephrosis,
hypothyroidism, familial combined hyperlipidemia
|
++ |
N |
| IIb |
Clear |
LDL, VLDL |
Familial combined hyperlipidemia
|
++ |
+ |
| III |
Turbid |
IDL |
Dysbetalipoproteinemia
|
+ |
+ |
| IV |
Turbid |
VLDL |
Familial hypertriglyceridemia, familial combined hyperlipidemia, sporadic
hypertriglyceridemia, diabetes
|
N+ |
++ |
| V |
Creamy top, turbid bottom |
Chylomicrons, VLDL |
Diabetes |
+ |
++ |
Note that the WHO classification is simply a biochemical phenotypic classification
based on which lipoprotein is raised. Also the classification was devised before
the importance of HDL as a prognostic indicator was recognised.
* IDL = intermediate-density lipoproteins; LDL = low-density lipoproteins;
TC = total cholesterol; TG = triglycerides; VLDL = very low-density lipoproteins;
+ = increased; ++ = greatly increased; N= normal; N+ = normal or increased
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