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- Fuchs' corneal dystrophy
- a dominantly inherited disorder that
affects corneal endothelial cells (1)
- slowly progressive, bilateral corneal
dystrophy, which is typically first observed clinically in patients older than
50 years of age
- however can be seen in some patients in their late 20s
- characterised
by a progressive loss of endothelial cells with secretion of an abnormally thickened
basement membrane, leading to guttata formation
- there is a decline in
visual acuity as a result of deterioration of endothelial function and increasing
corneal thickness increases
Reference: - P.
Rosenblum, W.J. Stark and I.H. Maumenee et al., Hereditary Fuchs' dystrophy, Am
J Ophthalmol 90 (1980), pp. 45546
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