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Metoclopramide is an anti-emetic with a wide spectrum of activity that closely resembles that of phenothiazines. However, in addition to its central effect, it has a peripheral action on the gut. This means that it is superior to the phenothiazines in emesis that is associated with gastroduodenal, biliary or hepatic disease.
The European Medicines Agency's Committee on Medicinal Products for Human Use has reviewed the benefits and risks of the antiemetic metoclopramide. The review was done at the request of the French medicines regulatory agency (ANSM), following concerns over side effects and efficacy. The review confirmed the well known risks of neurological effects such as short-term extrapyramidal disorders and tardive dyskinesia. The conclusion of the review was that these risks outweigh the benefits in long-term or high-dose treatment.
The summary of product characteristics should be consulted before prescribing this drug.
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