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Classification of non Hodgkin's lymphoma (NHL)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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classification

Several different classification systems have been brought forward over the past few years but none have gained universal acceptance.

  • historically NHL was classified according to the International Working Formulation (IWF) as either low, intermediate or high grade based on the morphology and natural history (1).
  • currently the Revised European American Lymphoma (REAL)/WHOclassification is in use

REAL/WHOclassification

B-cell neoplasms

  1. Precursor B-cell neoplasm: precursor B-acute lymphoblastic leukemia/lymphoblastic lymphoma (LBL).
  2. Peripheral B-cell neoplasms
  • B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma.
  • B-cell prolymphocytic leukemia.
  • Lymphoplasmacytic lymphoma/immunocytoma.
  • Mantle cell lymphoma.
  • Follicular lymphoma.
  • Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type.
  • Nodal marginal zone B-cell lymphoma (± monocytoid B-cells).
  • Splenic marginal zone lymphoma (± villous lymphocytes).
  • Hairy cell leukemia.
  • Plasmacytoma/plasma cell myeloma.
  • Diffuse large B-cell lymphoma.
  • Burkitt lymphoma.

T-cell and putative NK-cell neoplasms

  1. Precursor T-cell neoplasm: precursor T-acute lymphoblastic leukemia/LBL.
  2. Peripheral T-cell and NK-cell neoplasms.
  • T-cell chronic lymphocytic leukemia/prolymphocytic leukemia.
  • T-cell granular lymphocytic leukemia.
  • Mycosis fungoides/Sézary syndrome.
  • Peripheral T-cell lymphoma, not otherwise characterized.
  • Hepatosplenic gamma/delta T-cell lymphoma.
  • Subcutaneous panniculitis-like T-cell lymphoma.
  • Angioimmunoblastic T-cell lymphoma.
  • Extranodal T-/NK-cell lymphoma, nasal type.
  • Enteropathy-type intestinal T-cell lymphoma.
  • Adult T-cell lymphoma/leukemia (human T-lymphotrophic virus [HTLV] 1+).
  • Anaplastic large cell lymphoma, primary systemic type.
  • Anaplastic large cell lymphoma, primary cutaneous type.
  • Aggressive NK-cell leukemia.

Reference:

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