This site is intended for healthcare professionals
Login | Register | Univadis Login
Medical search

familial spastic paraplegia

FREE subscriptions for doctors and students... click here
You have 3 open access pages.

This is a hereditary neurodegenerative disorder which in its simple form results in a progressive spastic paraplegia. Patients present at any time from childhood to old age.

There are two main forms of the disease:

  • early onset with a very indolent course
  • later onset, 40-60 yrs, with occasional complicating features such as cerebellar ataxia, dementia and epilepsy

There is an important differential diagnosis.

Reference:

  • 1.Fink JK, Heiman PT, Bird T, et al. Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working group. Neurology 1996;46(6):1507-14.
  • 2.Fink JK. Advances in hereditary spastic paraplegia. Current Opinion in Neurology 1997;10(4):313-8.
  • 3.Raskind WH, Pericak VM, Lennon F, Wolff J, Lipe HP, Bird TD. Familial spastic paraparesis: evaluation of locus heterogeneity, anticipation, and haplotype mapping of the SPG4 locus on the short arm of chromosome 2. American Journal of Medical Genetics 1997;74(1):26-36.

Links:

The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions LtdĀ®. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions LtdĀ® receives funding from advertising but maintains editorial independence. GPnotebook stores small data files on your computer called cookies so that we can recognise you and provide you with the best service. If you do not want to receive cookies please do not use GPnotebook.