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2,3 DPG

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2,3-diphosphoglycerate lowers the affinity of haemoglobin A for oxygen by binding to and stabilising deoxyhaemoglobin.

Hypoxia e.g. due to lung disease or high altitude, results in an adaptive rise in the concentrations of 2,3-DPG and an improvement in the quantity of oxygen delivered to the tissues.

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